Ryan had frequent blisters early in his career, but used the pickle brine proactively and swore that it cured his problem. A lot of folks had their doubts, and clearly, if it worked, it didn't work for everybody. But if Ryan's career is a singular case, it's about as compelling as a singular case can be. Electric bassists, particularly of the funky variety, have been known to use airplane glue to harden the tender skin around burst blisters, but obviously pitchers have a limit on the substances they can use.